HIV Replication 3D Medical Animation
- Length: 5:13
- Rating Average: 4.83 from 535 people
- View Count: 289330' favoriteCount='1730
- Author: drrufusrajadurai
Tags: 3d aids animation ccr5 cd4 cxcr4 dr hiv medical rajadurai replication rufus virus
it is a very excellent animation which explains the hiv replication very clearly. For free download of this video please visit my webpage http://rufusrajadurai.wetpaint.com/page/Download And other 3D animation videos visit http://rufusrajadurai.wetpaint.com/page/3D+Medical+Animation+Library Regards, Dr.Rufus The Lyrics of this video is here Targeting HIV replication The replication of HIV 1 is a multi-stage process. Each step is crucial to successful replication and is therefore a potential target of antiretroviral drugs. Step one is the infection of a suitable host-cell, such as a CD4-positive T-lymphocyte. Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 -- receptors and co-receptors such as CCR5 or CXCR4. These receptors interact with protein-complexes, which are embedded in the viral envelope. These complexes are composed of two glycoproteins: an extracellular gp 120 and a transmembrane gp 41 When HIV approaches the target cell gp120 binds to the CD4-receptors. This process is termed attachment. It promotes further binding to a co-receptor. Co-receptor binding results in a conformational change in gp120. This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane. Gp 41 then folds back on itself. This draws the virus towards the cell and facilitates the fusion of their membranes. The viral nucleocapsid enters the host cell and breaks open releasing two viral RNA-strands and 3 essential replication enzymes: Integrase, Protease and Reverse Transcriptase. Reverse Transcriptase begins the reverse transcription of viral RNA. It has two catalytic domains: The Ribonuclease-H active site And the polymerase active site Here single stranded viral RNA is transcribed into an RNA-DNA double helix. Ribonuclease- H breaks down the RNA. The polymerase then completes the remaining DNA-strand to form a DNA -- double helix. Now Integrase goes into action. It cleaves a dinucleotide from each 3-prime end of the DNA creating two sticky ends. Integrase then transfers the DNA into the cell nucleus and facilitates its integration into the host cell genome. The host cell genome now contains the genetic information of HIV. Activation of the cell induces transcription of proviral DNA into messenger RNA. The viral messenger RNA migrates into the cytoplasm where building blocks for a new virus are synthesised. Some of them have to be processed by the viral protease. Protease cleaves longer proteins into smaller core proteins. This step is crucial to create an infectious virus. Two viral RNA-strands and the replication enzymes then come together and core proteins assemble around them forming the capsid. This immature particle leaves the cell acquiring a new envelope of host and viral proteins. The virus matures and becomes ready to infect other cells. HIV replicates billions of times per day destroying the hosts` immune cells and eventually causing disease progression. Drugs which interfere with the key steps of viral replication can stop this fatal process. Entry into the host cell can be blocked by fusion inhibitors for example. Inhibition of reverse transcriptase by nucleoside inhibitors or by non-nucleoside Reverse Transcriptase- inhibitors is part of standard antiretroviral regimens. The action of Integrase can be blocked. Protease inhibitors are also part of standard antiretroviral therapy. Each blocked step in viral replication is a step towards better control of HIV disease. Script, Storyboard, Art Direction by: Frank Schauder, MD Animation: MACKEVISION Publicity: Dr.Rufus Rajadurai.M.D.,D.DENS.,
HIV virus
- Length: 2:35
- Rating Average: 4.40 from 70 people
- View Count: 103652' favoriteCount='259
- Author: auxv
Process of HIV virus cell entry.
Possible HIV Cure?
- Length: 3:25
- Rating Average: 5.00 from 91 people
- View Count: 57153' favoriteCount='104
- Author: CBS
Tags: cure discovered hiv houston lee texas virus
Two doctors in Houston, Texas, believe they might have discovered the Achilles heel of the HIV virus. KHOU's Lee McGuire reports.
HIV/AIDS in Zimbabwe
- Length: 4:36
- Rating Average: 4.47 from 216 people
- View Count: 174904' favoriteCount='228
- Author: bluehorse678
Tags: Africa AIDS Casting Children Crowns Free HIV Zimbabwe
this is a video that i did for my english class. I wrote a research paper on the HIV/AIDS crisis in Zimbabwe and to help put my paper into perspective, i made this video to go along with it.
Lee Evans Speaks Out about the HIV Tests
- Length: 4:58
- Rating Average: 4.24 from 272 people
- View Count: 65829' favoriteCount='141
- Author: theaidstrial
Olympic Gold Medal winner Lee Evans discusses the myriad of problems with the HIV tests that are incorrectly diagnosing people as HIV-Positive.
Did I Just Contract HIV? Symptoms of Primary HIV Infection
- Length: 4:49
- Rating Average: 4.62 from 179 people
- View Count: 159787' favoriteCount='106
- Author: AIDSvideos
Tags: aids fatigue fever genital hiv infection joint lymph mouth nausea nodes primary rash sore symptoms test throat vomiting
It's sometimes possible to recognize when you've recently contracted HIV from signs and symptoms such as fever, rash, or swollen lymph nodes. This video will teach you how to recognize signs and symptoms of primary HIV infection that are experienced by between 40 and 90% of individuals after they are first infected with HIV. Primary HIV infection occurs during the first few weeks or months after a person first becomes infected with HIV. Symptoms include rash and/or fevers, possibly in combination with one or more of the following symptoms: malaise (which is a general feeling of weakness, discomfort, and fatigue), loss of appetite, weight loss, a sore throat, sores in the mouth, joint or muscle pain, swollen lymph nodes, diarrhea, fatigue, night sweats, nausea and vomiting, headache, or genital sores. The symptoms usually last from seven to ten days, and rarely more than two weeks. There is an incubation period of a few days to a few weeks between when the person was exposed to HIV and when the symptoms begin. If you have any of these symptoms and think there's even the slightest chance you might have been exposed to HIV, such as through recent sexual activity or sharing a needle, even with someone who you believe is HIV negative, you should see a doctor and ask to be tested for HIV. When you go to the doctor with any of these symptoms, it's very important to mention any risk factors you may have for HIV so they could test you. If you have ever had unprotected sex, even once, have used injection drugs, or think you might be experiencing primary HIV infection, make sure to tell your doctor. Visit http://www.GlobalLifeworks.org and http://AIDSvideos.org to learn more. [Do you want to help prevent the spread of HIV/AIDS? Are you fluent in a language other than English? Then volunteer to translate this video into another language! Click http://AIDSvideos.org/translate.shtml to to learn how you can help!!!]
HIV 101
- Length: 10:33
- Rating Average: 4.72 from 120 people
- View Count: 33834' favoriteCount='180
- Author: revrobertdavis
Basic info on HIV and AIDS.
"Spotlight: HIV/AIDS"
- Length: 5:26
- Rating Average: 4.26 from 19 people
- View Count: 19729' favoriteCount='25
- Author: lafinlys
Tags: AIDS HIV Spotlight world
2 shows on HIV/AIDS, aired Nov 29 and Dec 1s5 2005. also show on Global Development
Bayer Exposed ( HIV Contaminated Vaccine )
- Length: 3:17
- Rating Average: 4.86 from 384 people
- View Count: 89379' favoriteCount='604
- Author: octomedia
Tags: AIDS Bayer contaminated Drug Exposed HIV Infected KILLED KILLER LIES octomedia profit vaccine
http://www.whale.to/vaccines.html [Video] Bayer Sells AIDS-Infected Drug Banned in U.S. in Europe, Asia - Unearthed documents show that the drug company Bayer sold millions of dollars worth of an injectable blood-clotting medicine -- Factor VIII concentrate, intended for hemophiliacs -- to Asian, Latin American, and some European countries in the mid-1980s, although they knew that it was tainted with AIDS. Bayer knew about the fact that the drug was tainted and told the FDA to keep things under wraps while they made a profit off of a drug that infected its patients. If these allegations are true, then both Bayer and the FDA are at fault for this catastrophe. FDA regulators helped to keep the continued sales hidden, asking the company that the problem be ''quietly solved without alerting the Congress, the medical community and the public,'' according to the minutes of a 1985 meeting octomedia Vaccine Information and Awareness sites: http://thinktwice.com/ http://www.vaclib.org/
HIV Resistance
- Length: 5:21
- Rating Average: 4.75 from 28 people
- View Count: 11429' favoriteCount='71
- Author: drrufusrajadurai
Tags: 3d aids animation hiv medical model resistance
a detailed 3d animation about hiv resistance in organism visit my website for more medical animations and their downloads: http://rufusrajadurai.wetpaint.com/
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